Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 143
interventional 120
Observational 19
Registry 4

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Device 55
Drug 11
Device|Other 10
Other 10
Procedure 9
Biological 6
Drug|placebo 6
Biological|placebo 2
Drug|Procedure 2
Behavioral 1
Combination Product|Other 1
Device|placebo 1
Dietary Supplement 1
Dietary Supplement|placebo 1
Drug|Other 1
Genetic 1
Other|Procedure 1
placebo|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 44
France 12
United Kingdom 11
NA 5
Switzerland 4
Netherlands 3
United States|Canada 3
Ireland 2
Israel 2
Italy 2
Russian Federation 2
Thailand 2
Belgium|Germany|Netherlands|United Kingdom 1
Canada 1
Czech Republic 1
Denmark|France 1
Denmark|France|Germany|Poland|United Kingdom 1
Denmark|France|Germany|Spain 1
Denmark|Germany|Spain 1
Dominican Republic|Panama 1
France|Germany|Ireland|United Kingdom 1
France|United Kingdom 1
Germany 1
Germany|Czech Republic|France|Netherlands 1
Germany|Netherlands|Poland|United Kingdom 1
New Zealand 1
Norway 1
Poland 1
Poland|United Kingdom 1
Spain 1
Sweden 1
Turkey 1
United States|Argentina|Austria|Brazil|Canada|Czechia|Denmark|Germany|Hungary|Italy|Poland|Slovakia|Spain 1
United States|Australia|New Zealand|South Africa 1
United States|Austria|Estonia|Germany|Poland|South Africa|Sweden|United Kingdom 1
United States|Canada|Puerto Rico 1
United States|Canada|United Kingdom 1
United States|Estonia|Germany|Poland|South Africa|United Kingdom 1
United States|New Zealand 1
Uruguay 1

Sites per Study

Site_count Study_Count
1 55
2 13
3 8
4 3
5 3
6 4
7 4
8 2
9 1
10 2
11 1
12 2
13 2
15 1
16 1
17 2
20 1
21 1
22 1
27 1
28 1
30 1
33 1
34 2
35 1
43 1
44 1
50 1
56 1
70 1
90 1

Phase

Phase Study_Count
N/A 68
Phase 2 21
Phase 4 10
Phase 3 9
Phase 1 7
Phase 1/Phase 2 4
Phase 2/Phase 3 1

Number of Arms

Number_of_Arms Count_of_Studies
1 24
2 72
3 8
4 3
5 1
6 1
NA 11

Enrollment Metrics by Phase

Measure N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 5.00000 4.00000 30.00 5.00000 250 18 13.00
1st Qu. 29.50000 10.75000 37.50 35.00000 250 65 37.50
Median 80.00000 20.50000 100.00 60.00000 250 225 105.50
Mean 99.57353 28.16667 106.75 93.71429 250 243 119.50
3rd Qu. 140.00000 44.50000 169.25 122.00000 250 425 197.75
Max. 450.00000 64.00000 197.00 300.00000 250 537 266.00

Trial Group Type

group_type Group_Count
Experimental 98
Active Comparator 65
Placebo Comparator 20
Other 16
No Intervention 11
NA 11
Sham Comparator 5

Intervention Model

intervention_model Study_Count
Parallel Assignment 81
Single Group Assignment 30
Crossover Assignment 8
Sequential Assignment 1

Primary Purpose

primary_purpose Study_Count
Treatment 103
Other 5
Prevention 4
Diagnostic 2
Supportive Care 2
NA 2
Basic Science 1
Health Services Research 1

Observational Studies

Studies by Country

Country Study_Count
United States 7
France 5
Belgium|Czechia|Germany|Hungary|Poland 1
Canada 1
Ireland 1
NA 1
Norway 1
United States|Canada 1
United States|Sierra Leone 1

Sites per Study

Site_count Study_Count
1 15
4 1
6 1
30 1
43 1

Enrollment Metrics

Measure Observational
Min 34.0000
1st Qu 66.0000
Median 100.0000
Mean 156.6111
3rd Qu 217.2500
Max 550.0000

Observation Model

observational_model Study_Count
Cohort 11
Other 4
Case-Control 1
Case-Only 1
Case Control 1
NA 1

Time Perspective

time_perspective Study_Count
Prospective 13
Cross-Sectional 2
Retrospective 2
Other 1
NA 1

Registries

Studies by Country

Country Study_Count
United States 3
United States|Canada 1

Sites per Study

Site_count Study_Count
1 3
14 1

Enrollment Metrics

Measure Registries
Min 50
1st Qu 74
Median 5041
Mean 46283
3rd Qu 51250
Max 175000

Registry Model

observational_model Study_Count
Cohort 2
Case-Only 1
Other 1

Time Perspective

time_perspective Study_Count
Prospective 4

Follow-up

target_duration Study_Count
1 Month 1
12 Months 1
3 Months 1
5 Months 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04461132 The Effect of Manual Lymphatic Drainage https://ClinicalTrials.gov/show/NCT04461132 Completed Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey 2019-07-03
NCT04181320 A Multicentre European Study to Evaluate Granulox® Used in the Treatment Pathway of Predominantly Chronic Venous Leg Ulcers (VLUs). https://ClinicalTrials.gov/show/NCT04181320 Recruiting Molnlycke Health Care AB 2022-09-30
NCT03286140 Early Venous Reflux Ablation Ulcer Trial https://ClinicalTrials.gov/show/NCT03286140 Completed Imperial College London 2019-03-31
NCT03250247 Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial) https://ClinicalTrials.gov/show/NCT03250247 Recruiting Washington University School of Medicine 2021-12-31
NCT03186560 Speckle Study: In Arterial, Mixed and Diabetic Foot Ulcers https://ClinicalTrials.gov/show/NCT03186560 Recruiting Firstkind Ltd 2020-12-31
NCT03154619 Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers https://ClinicalTrials.gov/show/NCT03154619 Recruiting SerenaGroup, Inc. 2019-11-30
NCT03146845 Evaluation Of An Advanced Borderless Dressing https://ClinicalTrials.gov/show/NCT03146845 Completed Smith & Nephew, Inc. 2018-06-12
NCT03104985 LLLT of Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency https://ClinicalTrials.gov/show/NCT03104985 Completed Research Center Matrix 2015-12-31
NCT03077165 Dose-response Relationship Study of S42909 on Leg Ulcer Healing https://ClinicalTrials.gov/show/NCT03077165 Completed Ilkos Therapeutic Inc. 2019-12-12
NCT03057080 The Role of Percutaneous Angioplasty in Ischemic Leg Ulcer Healing https://ClinicalTrials.gov/show/NCT03057080 Completed University of Crete 2015-06-01
NCT03021811 EUREKA Italy - Evaluation of Real-life Use of KLOX BioPhotonic System in Chronic Wounds Management https://ClinicalTrials.gov/show/NCT03021811 Completed KLOX Technologies Inc. 2016-12-31
NCT02973893 Study of VF001-DP in Patients With Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02973893 Active, not recruiting Factor Therapeutics Ltd. 2018-11-30
NCT02896725 Wool-derived Keratin Dressings for Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02896725 Completed University of Auckland, New Zealand 2019-02-28
NCT02889926 Utility of Samples in Bacteriological Prospective Series of Ulcers Leg Infected Clinically https://ClinicalTrials.gov/show/NCT02889926 Active, not recruiting Groupe Hospitalier Paris Saint Joseph 2019-01-18
NCT02884323 A Study in Patients With Venous Leg Ulcers and Measuring the Effects of Using Gekoâ„¢ Device https://ClinicalTrials.gov/show/NCT02884323 Active, not recruiting Firstkind Ltd 2018-07-16
NCT02863068 Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers https://ClinicalTrials.gov/show/NCT02863068 Recruiting Montefiore Medical Center 2021-12-30
NCT02729688 Effectiveness of a Pressure Indicator Guided and a Conventional Bandaging in Treatment of Venous Leg Ulcer https://ClinicalTrials.gov/show/NCT02729688 Completed Mahidol University 2017-03-01
NCT02728986 Cost Evaluation of Venous Leg Ulcers Management https://ClinicalTrials.gov/show/NCT02728986 Completed 3M 2018-06-01
NCT02696460 Efficacy of 50% Nitrous Oxide/50% Oxygen Gas Premix in Chronic Leg Ulcer Debridement https://ClinicalTrials.gov/show/NCT02696460 Completed Venenklinik Bellevue 2011-10-31
NCT02652572 Safety Study to Examine the Systemic Exposure of Granexin® Gel After Topical Application to Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02652572 Completed FirstString Research, Inc. 2017-12-31
NCT02632695 Physical Activity Interventions for Leg Ulcer Patients https://ClinicalTrials.gov/show/NCT02632695 Completed Medical University of South Carolina 2018-08-31
NCT02626156 Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence https://ClinicalTrials.gov/show/NCT02626156 Completed Medical University of South Carolina 2020-03-31
NCT02609594 Amnioband and Standard of Care vs. Standard of Care Alone in the Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02609594 Recruiting SerenaGroup, Inc. 2018-12-31
NCT02600390 SANGUINATEâ„¢ in Sickle Cell Disease Associated Leg Ulcer https://ClinicalTrials.gov/show/NCT02600390 Completed Prolong Pharmaceuticals 2016-10-31
NCT03277131 DURAFIBER Ag Post-Market Clinical Follow-Up https://ClinicalTrials.gov/show/NCT03277131 Completed Smith & Nephew, Inc. 2019-06-19
NCT03396731 Efficacy Study for Geko Device in VLU Patients https://ClinicalTrials.gov/show/NCT03396731 Recruiting Firstkind Ltd 2020-09-30
NCT02482038 Geko Venous Leg Ulcer Study https://ClinicalTrials.gov/show/NCT02482038 Completed Firstkind Ltd 2018-06-05
NCT02470806 Single-Use Negative Pressure Wound Therapy System vs. Traditional Negative Pressure Wound Therapy System (tNPWT) https://ClinicalTrials.gov/show/NCT02470806 Completed Smith & Nephew, Inc. 2017-11-14
NCT02422017 Topical Timolol Benefit in Venous Ulcers https://ClinicalTrials.gov/show/NCT02422017 Completed Centre Hospitalier Universitaire, Amiens 2016-05-31
NCT02395302 Evaluation of a Dual Action Pneumatic Compression System: Tolerance and Comfort in Patients With Venous Leg Ulcers (VLUs) https://ClinicalTrials.gov/show/NCT02395302 Completed Tactile Medical 2015-09-30
NCT02392390 Effects of Topical Dynamic Phototherapy on the Microbiota of Chronic Wounds https://ClinicalTrials.gov/show/NCT02392390 Completed Centre Hospitalier Universitaire de NÄ«mes 2016-03-31
NCT02312518 A Prospective, Randomized Clinical Trial of PRP Concepts Fibrin Bio-Matrix in Chronic Non-Healing Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02312518 Recruiting PRP Concepts, LLC 2021-03-31
NCT02222467 Safety Evaluation of the KLOX BioPhotonic System in Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02222467 Completed KLOX Technologies Inc. 2015-04-30
NCT02167815 A Multicenter, Post Marketing Clinical Follow up (PMCF) Investigation to Evaluate the Performance and Safety of a Soft Silicone Foam Dressing and to Evaluate the Performance of Standard Care in Exuding Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02167815 Completed Molnlycke Health Care AB 2015-07-31
NCT02158806 Low Dose Aspirin for Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02158806 Completed University of Auckland, New Zealand 2017-03-31
NCT02104180 Evaluation of Pain Associated With the Removal of Wound Dressing During Care of Venous Leg Ulcer. Comparison of the Efficacy and Safety of Two Dressings Urgotul and TulleGras https://ClinicalTrials.gov/show/NCT02104180 Completed Mylan Inc. 2016-03-31
NCT01316796 Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood Disorders https://ClinicalTrials.gov/show/NCT01316796 Completed National Institutes of Health Clinical Center (CC) 2015-09-18
NCT02045303 Healing Rate of Leg Wounds Treated With Contact and Noncontact Ultrasound: The VIP Ultrasound Protocol https://ClinicalTrials.gov/show/NCT02045303 Completed Texas Health Resources 2015-08-31
NCT02020746 Efficacy and Safety Study of EscharEx to Treat (Debride) Hard to Heal Wounds https://ClinicalTrials.gov/show/NCT02020746 Completed MediWound Ltd 2017-12-05
NCT02011503 Use of dHACM in the Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02011503 Completed MiMedx Group, Inc. 2017-08-05
NCT01964911 To Assess Analgesia Provided by Continuous Sciatic Nerve Block in Patients With Hypertensive Leg Ulcer https://ClinicalTrials.gov/show/NCT01964911 Completed Nantes University Hospital 2018-01-31
NCT01891760 Long-Term Follow-Up to the DEVO Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01891760 Completed Shire Regenerative Medicine, Inc. 2012-06-30
NCT01801891 Surface NeuroMuscular Electrical Stimulation in the Treatment of Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01801891 Completed Mid Western Regional Hospital, Ireland 2014-09-30
NCT01770509 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study https://ClinicalTrials.gov/show/NCT01770509 Completed M.D. Lederman Consulting Ltd 2015-02-28
NCT01750749 Cell Therapy for Venous Leg Ulcers Pilot Study https://ClinicalTrials.gov/show/NCT01750749 Completed Hospital de Clínicas Dr. Manuel Quintela 2013-12-31
NCT01743053 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01743053 Completed Avita Medical 2015-10-31
NCT01737762 Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2 https://ClinicalTrials.gov/show/NCT01737762 Completed Healthpoint 2015-11-30
NCT01673412 Research of Prognostic Factors Associated With Healing of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01673412 Completed Centre Hospitalier Universitaire, Amiens 2008-06-30
NCT01671748 MIST Ultrasound Therapy Compared to United Kingdom Standard Care for the Treatment of Non-healing Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01671748 Completed Cardiff and Vale University Health Board 2013-12-31
NCT01656889 Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01656889 Completed Healthpoint 2014-12-31
NCT01591434 Study to Evaluate the Performance of AQUACEL® Extra™ in Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01591434 Completed ConvaTec Inc. 2012-09-30
NCT00821431 Compression Device Versus 4-layer Compression System https://ClinicalTrials.gov/show/NCT00821431 Completed ConvaTec Inc. 2008-06-30
NCT01552447 Human Amniotic Membrane Grafting and Standard of Care Versus Standard of Care Alone in the Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01552447 Completed MiMedx Group, Inc. 2014-05-31
NCT01549860 Effects of Non Contact Low Frequency Ultrasound in Healing Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01549860 Completed Celleration, Inc. 2014-05-31
NCT01509599 Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation https://ClinicalTrials.gov/show/NCT01509599 Completed Medical University of South Carolina 2015-12-31
NCT01497210 EASH Dressing on Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01497210 Completed ConvaTec Inc. 2012-04-30
NCT01449422 Clinical Trial to Evaluate the Efficacy, Tolerance and Acceptability of URGO Dressing vs a Hydrofibre in the Local Management of Venous or Predominantly Venous Mixed Leg Ulcers. https://ClinicalTrials.gov/show/NCT01449422 Completed Laboratoires URGO 2013-01-31
NCT01427491 Compare Aquacel® Ag Versus Mepilex® Border Ag to Manage Bioburden in Leg Ulcers https://ClinicalTrials.gov/show/NCT01427491 Completed ConvaTec Inc. 2012-01-31
NCT03736941 Impact of Venotrain UlcerteC Venous Compression Device in the Treatment of Venous Ulcers in Daily Practice https://ClinicalTrials.gov/show/NCT03736941 Recruiting Groupe Hospitalier Paris Saint Joseph 2020-09-30
NCT01327937 A Post Marketing Study of Apligraf in Non-healing Wounds of Subjects With Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01327937 Completed Organogenesis 2013-11-30
NCT01319123 Evaluate the Impact of Drawtex in Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01319123 Completed Southwest Regional Wound Care Center 2011-08-31
NCT04240574 Debritom - Micro Water Jet Technology and Wound Healing https://ClinicalTrials.gov/show/NCT04240574 Recruiting Rosalind Franklin University of Medicine and Science 2021-01-31
NCT04123093 Safety and Efficacy of the Noxsano Wound Care Bandage https://ClinicalTrials.gov/show/NCT04123093 Active, not recruiting OhioHealth 2021-01-31
NCT04019340 The Impact of a Pluridisciplinary Education Program on Venous Leg Ulcer Size Reduction https://ClinicalTrials.gov/show/NCT04019340 Recruiting School of Health Sciences Geneva 2022-12-31
NCT04018924 Blu Light for Ulcers Reduction https://ClinicalTrials.gov/show/NCT04018924 Completed Emoled 2019-11-17
NCT03935386 Standard Compression Therapy With/Without Application of Skin Allograft (Theraskin) for Venous Leg Ulcer Treatment https://ClinicalTrials.gov/show/NCT03935386 Enrolling by invitation Solsys Medical LLC 2020-12-31
NCT03903692 A Comparative Evaluation of a MPS Dressing and a CMC Dressing on Subjects With Lower Extremity Venous Ulcers https://ClinicalTrials.gov/show/NCT03903692 Recruiting Medline Industries 2021-06-01
NCT03881267 SkinTEâ„¢ in the Treatment of Venous Leg Wounds https://ClinicalTrials.gov/show/NCT03881267 Recruiting Professional Education and Research Institute 2020-09-30
NCT03818828 Subjects With Non-Healing Venous Leg Ulcers Treated With Standard Care Plus Cryopreserved Human Umbilical Cord (TTAX01) https://ClinicalTrials.gov/show/NCT03818828 Active, not recruiting Tissue Tech Inc. 2020-01-31
NCT03796793 Developing Strategies for Effective Debridement in Patients for Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT03796793 Recruiting University of Miami 2023-04-30
NCT03716167 Randomized Controlled Trial for Treatment of Pain and Assessment of Wound Healing in Chronic Venous Leg Ulcers Using Near Infrared Laser Therapy https://ClinicalTrials.gov/show/NCT03716167 Active, not recruiting Wake Forest University Health Sciences 2020-10-31
NCT03699072 DermaRepâ„¢ Device in the Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT03699072 Recruiting Biovotec AS 2020-01-31
NCT03667937 Effectiveness of a Hydrophobic Dressing for Microorganisms’ Colonization and Infection Control of Vascular Ulcers https://ClinicalTrials.gov/show/NCT03667937 Recruiting University of Malaga 2020-12-30
NCT03666754 Early Glue Saphenous Vein Ablation With Compression Versus Compression Alone in the Healing of the Venous Ulcer https://ClinicalTrials.gov/show/NCT03666754 Recruiting Mahidol University 2020-12-31
NCT03662997 Clinical Study to Compare 3 Multi-Layered Foam Dressings for the Management of Chronic Wounds https://ClinicalTrials.gov/show/NCT03662997 Completed Molnlycke Health Care AB 2019-10-01
NCT03644849 Evaluating the Safety and Efficacy of Fractionated Carbon Dioxide Therapy in Postoperative Lower Extremity Wound Healing https://ClinicalTrials.gov/show/NCT03644849 Recruiting St. Louis University 2020-06-30
NCT03640689 DEep VEin Lesion OPtimisation (DEVELOP) Trial https://ClinicalTrials.gov/show/NCT03640689 Recruiting National University of Ireland, Galway, Ireland 2024-09-01
NCT03621592 VLU Dressing Study https://ClinicalTrials.gov/show/NCT03621592 Recruiting University of Miami 2020-12-31
NCT03594344 Additional Hyperbaric Oxygen After Lower Extremity Amputation https://ClinicalTrials.gov/show/NCT03594344 Recruiting Oslo University Hospital 2022-12-31
NCT03593369 Assessment of the Evolution of Wound Biomarkers in Venous Leg Ulcers Treated With KLOX Biophotonic System https://ClinicalTrials.gov/show/NCT03593369 Recruiting KLOX Technologies Inc. 2020-03-31
NCT03589586 Clinical Effectiveness of DermACELL AWM in Subjects With Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT03589586 Recruiting LifeNet Health 2020-06-30
NCT03588130 A Study to Evaluate the Safety and the Efficacy of EscharEx (EX-02 Formulation) in Debridement of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT03588130 Recruiting MediWound Ltd 2021-08-31
NCT03576989 Impact of Omega-3 Fatty Acid Oral Therapy on Healing of Chronic Venous Leg Ulcers in Older Adults https://ClinicalTrials.gov/show/NCT03576989 Recruiting Ohio State University 2023-03-31
NCT03468816 Wound Dressing With Moisture Sensor https://ClinicalTrials.gov/show/NCT03468816 Completed VÃ¥rdcentralen Ã…by 2019-11-22
NCT03454698 Education for Venous Leg Ulcer Patients https://ClinicalTrials.gov/show/NCT03454698 Completed School of Health Sciences Geneva 2018-10-31
NCT01238419 Physiotulle vs Urgotul in the Treatment of Leg Ulcer https://ClinicalTrials.gov/show/NCT01238419 Completed Coloplast A/S 2011-05-31
NCT01199588 A Study to Investigate the Efficacy, Safety and Tolerability of Nexagon® as a Topical Treatment for Subjects With Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01199588 Completed OcuNexus Therapeutics, Inc. 2012-12-31
NCT01153633 Trial on the Efficacy of Prontosan Wound Irrigation Solution and Prontosan Wound Gel https://ClinicalTrials.gov/show/NCT01153633 Completed B. Braun Ltd. Centre of Excellence Infection Control 2011-10-31
NCT01138436 A Clinical Study of the Safety and Efficacy of MEBO Wound Ointment in Subjects With Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01138436 Completed Skingenix, Inc. 2011-10-31
NCT01111695 Evaluation of a Ionic Silver and Honey Preparation to Treat Chronic Wounds of the Lower Legs https://ClinicalTrials.gov/show/NCT01111695 Completed University Hospital, Geneva 2010-11-30
NCT01084577 AQUACEL® Ag Dressing and Urgotul® Silver Dressing on Healing of Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01084577 Completed ConvaTec Inc. 2011-01-31
NCT00970697 Becaplermin Gel for MARTORELL’s Hypertensive Leg Ulcers https://ClinicalTrials.gov/show/NCT00970697 Completed Assistance Publique - Hôpitaux de Paris 2009-05-31
NCT00909870 Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00909870 Completed Organogenesis 2011-05-31
NCT00852995 Dose Finding Study of HP802-247 in Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00852995 Completed Healthpoint 2011-04-30
NCT00825760 Clinical Trial to Investigate Treatment With Photodynamic Therapy to Reduce Levels of Bacteria in Leg Ulcers https://ClinicalTrials.gov/show/NCT00825760 Completed Photopharmica 2011-09-30
NCT00823446 Feasibility Study to Evaluate the Safety of Topically Applied Revera in Subjects With Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00823446 Completed Revalesio Corporation 2010-10-31
NCT03629236 Study to Evaluate Safety and Efficacy of GrafixPL for the Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT03629236 Active, not recruiting Osiris Therapeutics 2020-10-01
NCT00838500 THERMES ET VEINES: Spa for Prevention of Leg Ulcers https://ClinicalTrials.gov/show/NCT00838500 Completed Association Francaise pour la Recherche Thermale 2010-12-31
NCT00807664 Biatain Ag vs Biatain in the Treament of Leg Ulcers https://ClinicalTrials.gov/show/NCT00807664 Completed Coloplast A/S 2010-04-30
NCT01754506 Testing Fish Oil Derivatives In Healing Of Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT01754506 Completed Ohio State University 2015-07-31
NCT03112395 Local Application of Combined Optical and Magnetic Stimulation (COMS) for Treatment of Chronic Wounds: Safety Evaluation https://ClinicalTrials.gov/show/NCT03112395 Completed Piomic Medical AG 2020-06-04
NCT03126396 Assessment of Efficacy & Tolerance of Urgo 310 3166 Dressing in Local Venous or Mixed Leg Ulcers https://ClinicalTrials.gov/show/NCT03126396 Completed Laboratoires URGO 2018-05-22
NCT01036438 Evaluating the Efficacy of an Absorbent Foam Dressing Containing Silver (Mepilex Ag) Versus the Same Dressing Without Silver Used on Subjects With Venous Leg Ulcers or Mixed Ulcers https://ClinicalTrials.gov/show/NCT01036438 Completed Molnlycke Health Care AB 2013-10-31
NCT00764361 Safety Study of Topical Doxycycline Gel for Adult Diabetic Lower Extremity Ulcers https://ClinicalTrials.gov/show/NCT00764361 Completed NanoSHIFT LLC 2010-08-31
NCT00663091 A Prospective, Randomized, Double-Blind Controlled Study of WPP-201 for the Safety and Efficacy of Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00663091 Completed Southwest Regional Wound Care Center 2008-05-31
NCT00628004 Safety Evaluation of Biatain Ibu in Painful Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00628004 Completed Coloplast A/S 2009-07-31
NCT00627094 Biatain Ibu vs. Biatain in Painful Chronic Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00627094 Completed Coloplast A/S 2009-04-30
NCT00558662 Randomized Clinical Trial (RCT) to Compare the Efficacy of Coban 2 Versus SSB in the Treatment of Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00558662 Completed 3M 2009-04-30
NCT00399308 Evaluation of Safety and Activity of Celaderm in Healing Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00399308 Completed Shire 2008-04-30
NCT00820196 A Trial to Assess the Safety and Activity of Nexagon® for the Treatment of Venous Leg Ulcers (The NOVEL Study) https://ClinicalTrials.gov/show/NCT00820196 Completed OcuNexus Therapeutics, Inc. 2010-02-28
NCT00371371 Intra-arterial Stem Cell Therapy for Patients With Chronic Limb Ischemia (CLI) https://ClinicalTrials.gov/show/NCT00371371 Completed UMC Utrecht 2012-12-31
NCT00349700 Wound Dressings Adapted to Wound Exudate and Bacterial Load in Therapy Resistant Large Sized Leg Ulcers https://ClinicalTrials.gov/show/NCT00349700 Completed Ruhr University of Bochum NA
NCT00304837 VEGF Gene Transfer for Critical Limb Ischemia https://ClinicalTrials.gov/show/NCT00304837 Completed Losordo, Douglas, M.D. NA
NCT00301496 Randomized Controlled 8-Week Crossover Evaluation of Compression Bandage Systems for Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00301496 Completed 3M NA
NCT00288392 Efficacy of Soluble Beta-1,3/1,6-Glucan Compared to Placebo on Chronic Leg Ulcers in Diabetes Patients https://ClinicalTrials.gov/show/NCT00288392 Completed Biotec Pharmacon ASA NA
NCT00270946 Evaluation of Bilayered Cellular Matrix (OrCel) for the Treatment of Venous Ulcers https://ClinicalTrials.gov/show/NCT00270946 Completed Ortec International NA
NCT00243620 A Randomised Controlled Trial Comparing Vacuum Assisted Closure (V.A.C.®) With Modern Wound Dressings https://ClinicalTrials.gov/show/NCT00243620 Completed Maastricht University Medical Center NA
NCT00235209 A Study to Evaluate the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT00235209 Completed Ethicon, Inc. NA
NCT00184873 Legtest Multi Centre Testing of the Lively Legs Program for Promoting Compliance in Leg Ulcer Patients https://ClinicalTrials.gov/show/NCT00184873 Completed Radboud University 2008-05-31
NCT00007280 Bioengineered Skin and Wound Healing https://ClinicalTrials.gov/show/NCT00007280 Completed Roger Williams Medical Center 2005-08-31

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03290690 Positive Predictive Value (PPV) of Pseudomonas Aeruginosa https://ClinicalTrials.gov/show/NCT03290690 Recruiting MolecuLight Inc. 2020-07-30
NCT03086577 Pain in Chronic Leg- and Foot Ulcers https://ClinicalTrials.gov/show/NCT03086577 Recruiting University College of Southeast Norway 2018-02-21
NCT02904707 Interest of Skin Graft Pellets in the Management of Ulcers Algic https://ClinicalTrials.gov/show/NCT02904707 Completed Groupe Hospitalier Paris Saint Joseph 2015-05-31
NCT02889913 When Asking the Indication of a Skin Biopsy From a Patient With a Leg Ulcer in Primary Care? https://ClinicalTrials.gov/show/NCT02889913 Completed Groupe Hospitalier Paris Saint Joseph 2015-07-31
NCT02156102 Insights Into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers Study (INSIGHTS Study) https://ClinicalTrials.gov/show/NCT02156102 Recruiting National Institutes of Health Clinical Center (CC) 2021-12-31
NCT01970657 Observational Study Providing 12 Months of Safety Follow-Up From First Exposure to HP802-247 https://ClinicalTrials.gov/show/NCT01970657 Completed Healthpoint 2015-11-30
NCT01551667 Immune Response of Patients With Chronic, Staphylococcus Aureus-infected Wounds https://ClinicalTrials.gov/show/NCT01551667 Completed Centre Hospitalier Universitaire de NÄ«mes 2016-03-31
NCT04249661 Differential Effects of Bacteria Colonising Venous Leg Ulcers on Pain and Healing Rates https://ClinicalTrials.gov/show/NCT04249661 Recruiting University Hospital of Limerick 2021-01-09
NCT03955289 Treatment of Foot and Leg Ulcers Using a Laser https://ClinicalTrials.gov/show/NCT03955289 Completed University of Texas Southwestern Medical Center 2019-01-30
NCT03461549 Pressure and Temperature Sensor for Therapeutic Compression Garments https://ClinicalTrials.gov/show/NCT03461549 Recruiting Northwestern University 2021-03-31
NCT03444597 Post-Market Clinical-Follow-Up Study of Suprasorb® C Collagen Wound Dressing https://ClinicalTrials.gov/show/NCT03444597 Completed Lohmann & Rauscher 2020-01-23
NCT03416049 The Effects of Pulsed Elelectro-Magnetic Fields (“PEMF”) in the Treatment of Venous Stasis Leg Ulcers https://ClinicalTrials.gov/show/NCT03416049 Recruiting PEMF Systems, Inc. 2020-06-01
NCT00900029 Safety Follow-Up to HP 802-247-09-015 https://ClinicalTrials.gov/show/NCT00900029 Completed Healthpoint 2011-10-31
NCT02577120 Wound Healing Endpoint and Recurrence https://ClinicalTrials.gov/show/NCT02577120 Recruiting Indiana University 2020-12-31
NCT00759889 Obtaining and Storing Standard of Care Wound Biopsies for Immediate or Future Wound-Related Scientific Study https://ClinicalTrials.gov/show/NCT00759889 Completed Southwest Regional Wound Care Center 2018-12-30
NCT00710489 Potential Research Study Participant Registry https://ClinicalTrials.gov/show/NCT00710489 Completed University of California, Davis 2018-09-05
NCT00709631 Interest of a Systematic Biopsy for Hard-to-heal Leg Ulcers https://ClinicalTrials.gov/show/NCT00709631 Completed Assistance Publique - Hôpitaux de Paris 2009-06-30
NCT00522002 CLUE Study: Connective Tissue Disease Leg Ulcer Etiology Study https://ClinicalTrials.gov/show/NCT00522002 Completed George Washington University 2010-06-30
NCT00032864 Clinical Trial of Footwear in Patients With Diabetes https://ClinicalTrials.gov/show/NCT00032864 Completed VA Office of Research and Development NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT03257254 Effect of VarIthena on Wound Healing in Venous Leg Ulcers (VLU) https://ClinicalTrials.gov/show/NCT03257254 Active, not recruiting Provensis Ltd 2020-05-31
NCT02813187 Venous Leg Ulcer and Lymphedema Registry https://ClinicalTrials.gov/show/NCT02813187 Enrolling by invitation U.S. Wound Registry 2025-05-31
NCT02280733 A Real World, Observational Registry of Chronic Wounds and Ulcers https://ClinicalTrials.gov/show/NCT02280733 Recruiting U.S. Wound Registry 2025-01-31
NCT02047084 Comparison of Human Allograft to Apligraf for Venous Leg Ulcers https://ClinicalTrials.gov/show/NCT02047084 Enrolling by invitation Solsys Medical LLC 2019-12-31